Directions of Amoxicillin Capsules
【Drug name】
Generic name: Amoxicillin Capsules
English name: Amoxicillin Capsules
Chinese pronunciation spelling: Amoxillin Jiaonang
【Description】Capsule
【Pharmacology& Toxicity】 Benzylpenicillin antibacterial agent. It has exert potent antibacterial effects against gram-negative bacteria including Streptococcus such as Streptococcus pneumoniae, Streptococcus hemolyticus，Aerobic Gram-positive coccus such as staphylococcus whithout penicillinase production, Aerobic Gram-negative bacteria without BLPB production and Helicobacter pylori such as Escherichia coil,Bacillus proteus mirabilis sp., Salmonella， Haemophius influenzae，Neisseria gonorrhoeae, Amoxicillin inhibits compound of bacteria cell wall thus showing a bactericidal effect, and make bacteria become Corpuscles quickly followed by lyse and distruption.
【Pharmacokinetics】 Orally administrated, absorbed quickly. About 75% - 90% the dosage is absorbed by Gastrointestinal tract without food-dependent. Single orally 0.25 and 0.5g administrated, 1-2 hrs later, the blood concentration reached peaks (Cmax) of 3.5-5.0 and 5.5-7.5mg/L. Well distribute in all kinds of tissues and body fluid. 2 - 3 and 6 hrs later after single orally 0.5g administration to pneumonia or chronicity bronchitis acute patient, the concentration in sputum is 0.52 and 0.53mg/L but the corresponding blood concentration is 11 and 3.5mg/L. 1-2hrs later after single orally 1g administration to chronicity otitis media children, the concentration in middle ear fluid is 6.2mg/L. 2hs later after single orally 1g administration to tubercular meningitis patients,the concentration in cerebrospinal fluid is 0.1-1.5mg/L,approximately 0.9%-21.1% the corresponding blood levels.The drug can cross placental barrier. The concentration in belly band is 1/4-1/3 the maternal levels and in breast milk, sweat, tear is little. The eliminate half time (t1/2b) is 1-1.3 hrs. The plasma proteins binding rate is 17%-20%. 24%-33% the dosage is metabolized in hepar and 6hrs later, 45%-68% the dosage is in urine as the unchanged drug. The metabolite in bile is less. The serum half-life can be extended 7hrs in patients with severe impaired renal function. The drug can be eliminated by the blood serum dialysis instead peritoneal dialysis.
【Indications】It's indicated to treat following infections caused by susceptible strains(without BLPB production):
(1) Upper respiratory infection such as otitis media, nasosinusitis, pharyngitis, tonsillitis caused by Streptococcus hemolytic,Streptococcus pneumoniae,Staphylococcus sp.Or Haemophius influenzae. (2) Genitourinary infection caused by Escherichia coil,Bacillus proteus mirabilis.orEnterococcus. (3) Skin soft tissue infection caused by Streptococcus hemolytic,Staphylococcus sp.Or Escherichia coil.(4) lower respiratory infection such as acute bronchitis and pneumonia caused by Streptococcus hemolytic，Streptococcus pneumoniae，Staphylococcus sp. Or Haemophius influenzae. (5)acute simple gonorrhea; (6) typhoid fever，typhoid and leptospirosis; Stomach and dodecadactylon Helicobacter pylori can be eradicated by amoxicillin, Clarithromycin and lansoprazole administrated together. The Alimentary tract ulcer repea rate decrase.
【Dosage and Administration】 Orally. For adults, 0.5g every 6 8 hrs. Maximum dose is 4g at a time. Infants daily dosage is 20-40mg / kg, every 8 hours; 0-3 months older babies daily dosage is 30mg / kg, every 12 hours; The dosage may be adjusted to those who have a high degree of renal dysfunction. Patients whose endogenous creatinine clearance rate is 10-30ml / min is administered 0.25-0.5g every 12 hours; Patients whose endogenous creatinine clearance rate is not more than 10ml /per min is administered 0.25-0.5g every 24hours.
【Supply】0.25g（Calculated on the C16H19N3O5S.）
【Storage】Keep away from bright light. Tightly sealed
【Package】blister pack of 2,3and5 cards in boxes of 10 capsules; 2 cards in boxes of 12capsules.
【Validity】 one and half years
【Approval】Guo Yao Zhun Zi H12020807
|
